Easy Pizza Casserole Recipe

If you’re looking for a comforting, crowd-pleasing dish that comes together quickly and always satisfies, this Easy Pizza Casserole Recipe is absolutely the answer. It perfectly blends the best parts of a pizza—melty mozzarella, tangy pizza sauce, spicy pepperoni—layered with buttery biscuit pieces that soak up every bit of flavor. Whether you’re feeding a hungry family or hosting friends, this casserole offers layers of cheesy, saucy goodness that feel homemade without any fuss. Trust me, once you try this, it’ll become one of your go-to recipes for busy weeknights or casual get-togethers.

Ingredients You’ll Need

This Easy Pizza Casserole Recipe calls for a handful of simple ingredients that work together to create a deliciously cheesy, savory dish. Each one plays an important role—from the fluffy biscuit base that soaks up all the sauce and cheese, to the pepperoni that adds a perfect punch of flavor and spice.

• Buttermilk biscuits (2 cans, 1 lb each): These form the soft, fluffy layers that hold everything together and add a buttery richness.
• Pepperoni (7 oz package): Adds that classic zesty, slightly spicy taste that everyone loves on pizza.
• Mozzarella cheese (3-4 cups, divided): The key to gooey, melty layers of indulgent cheesiness.
• Pizza sauce (2 jars, 16 oz each, divided): Brings saucy, tangy flavor throughout the casserole, tying all ingredients together beautifully.
• Italian seasoning (1 tablespoon, divided): Adds fragrant herbs like oregano and basil to elevate every bite.
• Parmesan cheese (3-4 tablespoons, grated): Sprinkle on top for a salty, slightly nutty finish that browns beautifully in the oven.

How to Make Easy Pizza Casserole Recipe

Step 1: Get Your Oven Ready and Prep the Dish

Start by preheating your oven to 350 degrees Fahrenheit. Grease a deep 9×13 inch casserole dish thoroughly with nonstick spray so your casserole won’t stick and will bake evenly. Prepping the oven and dish upfront means everything will go smoothly once you assemble your ingredients.

Step 2: Cut and Layer the First Biscuit Base

Open the first can of biscuits and use kitchen scissors to cut each biscuit into six pieces: first cut in half, then each half cut into thirds. This creates bite-sized layers that will absorb the sauce and cheese perfectly. Spread these biscuit pieces evenly across the bottom of your casserole dish as the foundation.

Step 3: Add the First Layer of Pepperoni

Take half the package of pepperoni and cut each slice into quarters with your scissors. Scatter this over the biscuit pieces in the dish. This layer introduces a burst of meaty, slightly spicy flavor that makes pizza so irresistible.

Step 4: Sprinkle Mozzarella Cheese

Now add about 1 and 1/2 cups of mozzarella cheese in a generous layer on top of the pepperoni. This cheesy blanket will melt and bind the casserole layers together wonderfully.

Step 5: Spread the First Jar of Pizza Sauce

Open one jar of pizza sauce and spread it evenly over the mozzarella. The sauce adds moisture, tang, and signature Italian flavor throughout the dish. Make sure every corner gets some love so each bite is saucy.

Step 6: Season with Italian Herbs

Sprinkle half a tablespoon of Italian seasoning over the sauce layer to add an herbaceous note that rounds out the flavors with oregano, basil, and a touch of thyme.

Step 7: Layer the Second Biscuit Base and Pepperoni

Repeat the biscuit-cutting for the second can. Layer this on top of the seasoned sauce. Add the remaining half package of pepperoni, again cut into quarters, distributing evenly over the biscuits. Then spread half of the second jar of pizza sauce above the pepperoni and sprinkle the remaining half tablespoon of Italian seasoning.

Step 8: More Cheese, Please!

Sprinkle 1 to 2 cups of mozzarella cheese on top—the cheesier, the better! This extra layer guarantees that classic, chewy pizza goodness in every bite.

Step 9: Finish with Parmesan Cheese

Grate 3 to 4 tablespoons of Parmesan cheese and sprinkle it generously over the casserole’s top layer. This will create a golden, slightly crispy crust during baking, adding sophisticated flavor and texture.

Step 10: Cover and Bake Carefully

Spray a sheet of foil with nonstick spray and cover the casserole dish tightly. Set the casserole on a large baking sheet to catch any bubbling sauce that escapes during baking. This keeps your oven clean and makes handling easier.

Step 11: Bake Until Perfectly Cooked

Bake your casserole at 350°F for about 60 minutes. Then remove the foil and bake uncovered for another 10 to 15 minutes until the top is beautifully browned. To test doneness, poke a toothpick or fork in the middle—if it comes out clean, those biscuit layers are fully cooked. If not, cover and bake a little longer.

Step 12: Serve with Extra Pizza Sauce

Serve hot with the remaining half jar of pizza sauce warmed up on the side. It’s perfect for dipping and adds a little extra saucy kick that everyone appreciates.

How to Serve Easy Pizza Casserole Recipe

Garnishes

To make your casserole extra inviting, sprinkle fresh chopped basil or a pinch of red pepper flakes on top. The vibrant green of basil adds freshness and a lovely contrast to the rich layers, while red pepper flakes bring a subtle heat if you want to spice things up a bit.

Side Dishes

This casserole pairs wonderfully with a crisp green salad or roasted vegetables to balance out the richness. Something light and simple, like a classic Caesar or a garden salad with a tangy vinaigrette, complements all those cheesy, saucy flavors perfectly.

Creative Ways to Present

If you’re serving guests, consider scooping the casserole into individual ramekins for a personal touch. You might also top each serving with a drizzle of garlic-infused olive oil or a few extra slices of fresh mozzarella melted on top under the broiler for a luxe finish.

Make Ahead and Storage

Storing Leftovers

Store any leftover casserole in an airtight container in the refrigerator for up to 3-4 days. The flavors actually deepen after resting, making reheated portions just as delicious as freshly baked.

Freezing

You can freeze this pizza casserole before baking by assembling it in a freezer-safe dish, covering tightly with foil and plastic wrap, and freezing for up to 3 months. When ready to enjoy, bake it from frozen at 350°F, adding about 20 extra minutes to the baking time.

Reheating

To reheat, cover the casserole loosely with foil and warm it in a 350°F oven for 15-20 minutes or until heated through. Alternatively, single servings can be microwaved for a quick, no-fuss option. For the best texture, avoid overheating to keep the biscuits tender.

FAQs

Can I use homemade biscuit dough instead of canned?

Absolutely! If you prefer homemade biscuits, go for a sturdy but flaky dough that holds up well to layering and baking. Just cut them into similar-sized pieces and follow the same layering steps.

Is it possible to make this casserole vegetarian?

Yes! Simply omit the pepperoni and add extra vegetables like mushrooms, bell peppers, or olives for the meaty texture and flavor. You could also use plant-based pepperoni alternatives available in stores.

What kind of cheese works best for this casserole?

Mozzarella is the classic choice for that perfect melt and chewiness, but you can mix in provolone, cheddar, or a little fontina for added complexity and flavor.

Can I make this recipe gluten-free?

This casserole relies on biscuits, so you’d need to substitute with a gluten-free biscuit or bread alternative. There are great gluten-free biscuit mixes available that would work nicely in the same layered approach.

Do I have to prebake the biscuit layers?

No need! The biscuit pieces bake fully within the casserole, absorbing all the sauce and cheese flavors while cooking through. Just make sure to test for doneness with a toothpick as suggested.

Final Thoughts

If you want an effortless, satisfying dish that feels like pizza night and comfort food all wrapped into one, this Easy Pizza Casserole Recipe is the perfect pick. Its layers of flaky biscuits, melty mozzarella, zesty pepperoni, and aromatic herbs bring the cozy magic of pizza straight to your table with zero stress. Give it a try—once you do, it’ll be a recipe you love to make again and again!

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